Vaccines for the Prevention & Treatment of Breast Cancer
Unique amino acid sequences at the junctions of fusion or truncated proteins translated from chimeric RNAs form neoantigen peptide sites capable of inducing anti-tumor immune responses. Our objective is to find recurrent fusion transcripts that have the potential to generate candidate neoantigens presented by major histocompatibility complex class I (MHC I) during breast cancer progression. We comprehensively characterized the landscape of fusion transcripts in 225 samples of breast tumors representing 3 subtypes.
- 63/082,160 (Provisional, Pending)