Novel Compounds and Their Use for Treatment of Seizures
Epilepsy affects about 70 Million people worldwide and despite many available antiepileptic drugs (AEDs), pharmacotherapy of epilepsy remains a challenge.

This invention pertains to aryl-substituted acetamide and pyrrolidin-2-one derivatives and formulations with anti-seizure activity. These derivatives are expected to be useful in the treatment and prevention of seizures in the cases of epilepsy (including medically refractory epilepsy) and nerve agent poisoning.

These compounds have shown anti-seizure activity in drug-resistant (medically refractory)mice upon oral administration.Analogs of this compound are expected to have even better activity.
Applications
  • Medically refractory epilepsy
  • Nerve agent poisoning
Problems Addressed
  • Most of the currently available antiepileptic drugs (AEDs) have poor pharmacotherapy due to drug resistance, when the current first - line AEDs cannot control seizures in 24 -41% of patients
  • Side effects of effective AEDs limit their usage
Competitive Advantages
  • Fewer side- effects
  • Drug can be formulated in multiple dosage forms (tablets, capsules, pills, syrups/suspensions and suppositories)
Patents
  • 62/587,151
Case ID
2018-009
Inventor
Dr. Anton Dubrovskiy
Dr. Anton Dubrovskiy Assistant Professor, Department of Chemistry UH-Clear Lake