Biosensor for Detecting Single Magnetic Label
Magnetoresistive sensors (MR) are a possible alternative to fluorescent enzymatic biomarker assays for detecting presence or absence of a target molecule. This ultra-sensitive MR sensor is designed to digitally switch in the presence of single or multiple reporters. The detection of the reporter in this binding assay corresponds to the presence of a target molecule. This technology uses magnetic reporters that are stable enabling high sensitivity of detection. The inventors have already developed a prototype with complete software interface.
Applications
  • Diagnostic tool  
  • Research tool for biomarker detection
Problems Addressed
  • Fluorescent reporters require significant biomolecule to achieve high signal-noise ratio.  
  • Fluorescent reporters suffer from issues related to sample turbidity, auto-fluorescence and photo bleaching
  • Most MR sensors measure an analog resistance that is correlated to an amount of magnetic reporters.
Competitive Advantages
  • Sensitivity to detect molecules at low femtomole concentrations
  • Sensitivity 100X better than commercial fluorescent based platforms
Patents
  • Provisional Patent Application: 62/529,052
Case ID
2017-055
Inventor
Dmitri Litvinov
Professor of Electrical Engingeering
Additional Inventor Name
Long Chang
Research Assistant Professor of Integrated Bio and Nano Systems